Bills vs Texans TNF Preview: Odds, Streaming & Key Matchups
Thursday Night Football Showdown: Buffalo Bills at Houston Texans
The NFL's Week 12 slate kicks off with a primetime AFC showdown as the Buffalo Bills (7-3) travel to face the Houston Texans (5-5) at NRG Stadium. This marquee Thursday Night Football matchup features a fascinating contrast: the Bills' high-flying offense led by MVP candidate Josh Allen against the Texans' NFL #1-ranked defense. Kickoff is set for Thursday, November 20th at 8:15 PM ET.

Key Storylines to Watch
Josh Allen vs. Elite Texans Defense: Allen comes off a historic Week 11 performance where he threw three touchdown passes and rushed for three scores against Tampa Bay. The Texans counter with the NFL's top defense (scoring and total yards), allowing just 15.3 points per game. Their front seven and secondary rank in the top three against both run and pass, creating a formidable challenge for Buffalo's dual-threat quarterback.
Quarterback Adjustments: The Texans will be missing C.J. Stroud (concussion), with Davis Mills stepping under center for a second consecutive game. While Mills has shown poise, the Bills' defense ranks fifth in passing yards allowed and third in passing touchdowns surrendered. Buffalo, meanwhile, will be without key offensive weapons Dalton Kincaid and Keon Coleman.
Home-Field Dominance: Houston owns a remarkable 5-0 record against Buffalo at NRG Stadium, including last season's 23-20 victory. The Texans have also won five straight home games overall, creating a hostile environment for visitors.
Where to Watch: TV, Streaming & Radio
TV Broadcast: The game will air exclusively on Amazon Prime Video, featuring Al Michaels (play-by-play) and Kirk Herbstreit (color analysis) with Kaylee Hartung reporting from the sidelines.
Streaming Options:
- Prime Video app (included with Amazon Prime membership)
- NFL+ mobile app
- Twitch Prime Video channel
New users can start a 30-day Amazon Prime free trial to access the game. Canadian viewers can catch it on TSN or CTV2 networks.
Radio Broadcast: Bills fans can listen to Chris Brown (play-by-play), Eric Wood (analysis), and Sal Capaccio (sidelines) on the Bills Radio Network, with WGR Sports Radio 550 as the Buffalo flagship station.
Betting Odds & Predictions
The line has shifted from Buffalo opening as 2.5-point favorites to now -5 points, with the over/under set at 44.5. Buffalo is favored at -265 on the moneyline, while Houston sits at +215. Advanced models project a defensive battle with the Under hitting in over 50% of simulations.
"The Texans' defense has no holes on that side of the ball, with top-three rankings against the run, pass, and third downs. Houston also holds a significant edge in turnover differential (+7 vs. Buffalo's +1)." - Betting Analysis

Uniforms & Special Features
The Texans will sport their distinctive "Battle Red" alternate uniforms for the primetime contest, creating a monochromatic look at NRG Stadium. Amazon Prime Video will also offer "Prime Vision" with All-22 camera angles and Next Gen Stats for an enhanced viewing experience.
Final Analysis
Despite Buffalo's offensive firepower and Houston's defensive prowess, the short week after Sunday games adds fatigue factors. The Texans' home dominance and turnover margin could prove decisive, but Allen's ability to extend plays gives Buffalo the edge. Expect a low-scoring affair with defensive intensity throughout.
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Emily Rodriguez
Sports journalist covering international football, Olympics, and athlete profiles. Award-winning sports writer.